Pharmacokinetics and Bioequiavailability of Loratadine Tabletes in Healthy Volunteers / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-530997
ABSTRACT
OBJECTIVE:
To evaluate the bioequiavailability of two kinds of loratadine tabletes in Chinese healthy volunteers.METHODS:
A single oral dose 40 mg of two loratadine preparations(reference and test preparations)was given to 20 volunteers(whom were divided into two groups)in a randomized cross-over study.The concentration of loratadine in plasma was determined by solid phase extraction-HPLC.RESULTS:
The main pharmacokinetic parameters of reference and test preparations were as followsCmax were(17.00?3.90)and(18.41?2.58)?g?L-1;tmax were(1.06?0.25)and(0.93?0.20)h;t1/2Ke were(1.34?0.38)and(1.08?0.38)h;AUC0~∞ were(37.41?17.38)and(36.38?16.73)?g?h?L-1;AUC0~8 were(35.11?15.72)and(34.76?15.34)?g?h?L-1,respectively.The relative bioavailability of the test preparation was(99.0?18.7)% as against the reference preparation,and no significant differences was noted for the two formulations in ANOVA and two-one side t test.CONCLUSION:
The two formulations were bioequivalent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS