Effect of Lipid Diet on Pharmacokinetics of Gatifloxacin / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-531091
ABSTRACT
OBJECTIVE:
To study the effect of lipid diet on the pharmacokinetics of gatifloxacin.METHODS:
8 Beagle dogs were randomly assigned to receive single oral dose of gatifloxacin capsules(17 mg?kg-1) on empty stomach or in combination with lipid diet by a randomized crossover design plasma concentrations of gatifloxacin were measured by HPLC.The pharmacokinetic parameters were calculated by 3p97,and the effect of the lipid diet on the pharmacokinetics of gatifloxacin was evaluated.RESULTS:
The concentration-time curves fitted one compartment model in empty stomach group and lipide diet group.The main pharmacokinetic parameters were as follows t1/2ke were(4.00?0.84) and(7.87?1.54) h;tmax(2.29?1.08) and(3.61?2.72) h;Cmax(6.06?0.87) and(2.91?1.27) ?g?mL-1;AUC(0~t)(56.74?10.80) and(45.35?10.81) ?g?h?mL-1,respectively There were significant differences between the two groups in the t1/2Ke and Cmax(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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