Protective Effect of Captopril on Nicotine-induced Endothelial Dysfunction in Rats / 中国药房
China Pharmacy
; (12)2007.
Article
in Zh
| WPRIM
| ID: wpr-531092
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To discuss the protective effect of captopril on the nicotine-induced impairment of endothelium-dependent relaxation(EDR) in rat mesenteric arteries and explore the possible mechanisms underlying the observed protective effects of captopril.METHODS: A total of 30 rats were randomly divided into 3 groups: normal control group,nicotine group(2 mg?kg-1),captopril group(nicotine 2 mg?kg-1+captopril 3 mg?kg-1).After treatment for 4 weeks,vasodilatation rate of mesenteric arteries,the content of NO and NOS,and the SOD activities in serum were measured.RESULTS: Nicotine significantly decreased the vasodilatation rate of mesenteric arteries and decreased the content of NO and NOS,SOD activities in serum(P
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Index:
WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
2007
Type:
Article