Effects of radix pseudostellariae on cardiac function and matrix metalloproteinases in rat chronic heart failure induced by coronary artery ligation / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-531129
ABSTRACT
AIM:
To investigate the effects of radix pseudostellariae on cardiac function and matrix metalloproteinases(MMPs) in rat chronic heart failure induced by coronary artery ligation.METHODS:
Rat model of chronic heart failure was produced by ligating the coronary artery for 6 weeks.The cardiac functions were determined by observing the hemodynamics parameters.mRNA expressions of MMP-2 and MMP-9 in left ventricular tissue were detected by RT-PCR and activities of MMPs were assayed by zemography.RESULTS:
Cardiac function was remarkable turbulence after coronary artery ligation 6 weeks,according to the results of the hemodynamics.The mRNA contents and activities of MMP-2 and MMP-9 in left ventricular tissue were significantly elevated.Radix pseudostellariae remarkable ameliorated the cardiac functions,inhibited the mRNA contents and activities of MMP-2 and MMP-9 in left ventricular tissue of rat with chronic heart failure after continued 5 weeks treated with decoction of radix pseudostellariae.CONCLUSION:
The decoction of radix pseudostellariae ameliorates cardiac functions of rat with chronic heart failure.The mechanism maybe involves in the inhibition of the MMP-2 and MMP-9 mRNA expression and activities in cardiac ventricles.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1999
Type:
Article
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