Preparation and Release of Compound Alendronate Sodium Sustained-release Tablet in Vitro / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-531491
ABSTRACT
OBJECTIVE:
To prepare compound alendronate sodium sustained-release tablet and to investigate its drug release profile in vitro.METHODS:
Hydroxy propyl methylcellulose (HPMC), ethylcellulose (EC), and lactis anhydrous were used to prepare sustained-release tablets by wet granule compression technique with release rate in vitro as index. Orthogonal experiment was conducted to optimize the formula. The release rate of the tablets in vitro was investigated.RESULTS:
The optimized formula was as follows HPMC 80 mg, EC 20 mg, and lactis anhydrous 20 mg. 12 h drug release of the preparation was achieved, and the drug release behavior in vitro fitted Higuchi equation.CONCLUSION:
The sustained-release tablet is reasonable in formula and satisfactory in slow release efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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