Optimization of Nisoldipine Buccal Adhesive Tablets Formulation by Orthogoral Design / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-531494
ABSTRACT
OBJECTIVE:
To optimize the formulation of nisoldipine buccal adhesive tablets.METHODS:
The formulation was optimized by orthogonal design with the dosage ratio of carbopol to chitosan in drug-containing layer and protection layer, the content of lactose and the tabletting hardness as factors. The bioadhesiveness and in vitro drug release rate of the tablets was measured as well.RESULTS:
The optimal formulation was as follows the ratio of carbopol to chitosan in drug-containing layer and protection layer were 22.5∶22.5 and 33.3∶16.7 mg, respectively; the dosage of lactose was 10 mg, and tabletting hardness was 5 kg. The averge bioadhesiveness of 3 bacthes of optimized preparations was 79.5 g?cm-2, and the average in vitro drug release rate of the tablets in 12 h was more than 95%.CONCLUSIONS:
The optimized nisoldipine buccal adhesive tablets enjoy ideal bioadhesiveness and slow-release character.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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