Clinical Strategies to Develop Transplantation Tolerance / 한양의대학술지
Hanyang Medical Reviews
;
: 70-76, 2006.
Article
in Korean
| WPRIM
| ID: wpr-53158
ABSTRACT
The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using four different approaches; costimulatory blockade, mixed hematopoietic chimerism, T cell depletion, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes, Regulatory
/
Transplantation Tolerance
/
Chimerism
/
Allografts
/
Graft Survival
/
Immune Tolerance
/
Immunosuppressive Agents
Language:
Korean
Journal:
Hanyang Medical Reviews
Year:
2006
Type:
Article
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