Validation of Determination Method of the Content of Morphine in Compound Glycyrrhiza Oral Solution / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-531621
ABSTRACT
OBJECTIVE:
To validate the determination method of the content of Morphine in Compound Glycyrrhiza oral solution.METHODS:
Samples were detected by solid phase extraction-HPLC on Kromasil C8 column (250 mm?4.6 mm,5 ?m) with mobile phase consisted of 0.05 mol?L-1 KH2PO4-0.0 025 mol?L-1 C14H15NaO3S?2H2O-acetonitrile using gradient elution.The detection wavelength was 220 nm and the flow rate was 1.0ml.min-1.RESULTS:
The linear range of morphine was 2.02~20.2 ?g?mL-1(r=0.999 7),and the average recovery was 99.0%(RSD=0.40%,n=9).CONCLUSION:
The method is accurate,sensitive and stable,and accurate and reliable in determination results.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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