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Formula and Preparation Technology of Gel Matrix Sustained Release Tablet of Nicotinic Acid / 中国药房
China Pharmacy ; (12)1991.
Article in Zh | WPRIM | ID: wpr-531650
Responsible library: WPRO
ABSTRACT
OBJECTIVE: To optimize the formula and preparation technology of gel-matrix sustained release tablet of nicotinic acid(GSTNA).METHODS: The formula of GSTNA was optimized by orthogonal experiment with the amount of hydrophilic gel-matrix material HPMC(K15M,E15-LV) and that of adjuvant calcium hydrogen phosphate(CHP) as factors and with the in vitro release rates as index.Meanwhile,the verification test on the intra-and inter-batch release rates of the samples was performed.RESULTS: The optimum formula could be seen as follows: the ratios of HPMC(K15M,E15-LV) and CHP were 4%,40% and 25% respectively.The GSTNA prepared in this formula achieved a sustained drug release of up to 12 h,and both the intra-batch homogenicity and the inter-batch reproducibility were satisfactory.CONCLUSION: The GSTNA is reasonable in formula and simple in preparation technology.
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Full text: 1 Index: WPRIM Language: Zh Journal: China Pharmacy Year: 1991 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: China Pharmacy Year: 1991 Type: Article