Importance of Monitoring of Serum Concentration of Sodium Valproate in Epileptic Children / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the importance of monitoring serum concentration of Sodium Valproate(VPA)in the treatment of epileptic children.METHODS:Serum VPA concentration was determined by Chemiluminescence Enzyme Immunoassay(CLEIA),and the correlation between serum drug concentration and the daily dosage(mg?kg-1?d-1),dosage form,individual differences,blood sampling time and the clinical efficacy was analyzed.RESULTS:The serum VPA concentration which was lower than 50 mg?L-1 was found in 35.45% of the cases,and that which was higher than 100 mg?L-1 was found in 8.99%.CONCLUSION:The serum VPA concentration which was not in the therapeutic window can be resulted from multiple factors,and the monitoring results of the serum concentration should be analyzed comprehensively and made good use of.