Bioavailability of Single Oral Dose of Galanthamine Hydrobromide Extended-release Pellet Capsule in Dogs / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-531780
ABSTRACT
OBJECTIVE:
To study the bioavailability of single oral dose of galanthamine hydrobromide(GH) sustained-release pellet capsule (GHSRPC) in healthy dogs.METHODS:
By a two-cycle crossover trial, 6 dogs were randomly assigned to receive GHSRPC or GH capsules respectively by ig. Blood samples were taken at different time and the plasma concentrations of GHSRPC and GH capsules were determined by HPLC, meanwhile their pharmacokinetic parameters were computed.RESULTS:
After a single dose administration of GHSRPC and GH capsules, the pharmacokinetic parameters were as follows AUC were (1 867.24?321.05) and (1 604.60?289.17) ng?h?mL-1; tmax were (5.42?2.24) and (0.73?0.62) h; Cmax were (89.62?11.23) and (162.82?15.35) ng?mL-1; t1/2 were (8.93?1.82) and (7.58?1.21) h, respectively. The relative bioavailability of the GHSRPC was 116.36%.CONCLUSION:
The results showed significant sustained release characteristics of the GHSRPC, It’s bioequivalent with GH capsule.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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