Effects of Artesunate on Free Ca~(2+) Concentration in Human Prostatic Cancer PC-3 Cells / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-531890
ABSTRACT
OBJECTIVE:
To investigate the effects of artesunate(ART) on free Ca2+ concentration([Ca2+]i) in human prostatic cancer PC-3 cells.METHODS:
PC-3 cells were treated with ART and labeled using Ca2+ fluorescent probe Fluo-3/AM,and the change of[Ca2+]i was evaluated by confocal laser scanning microscopy.RESULTS:
After PC-3 cells were exposed to artesunate,the intracellular [Ca2+]i concentration increased significantly at 0~0.5 h,maintained at a high level at 0.5~1 h,but decreased to the level of the initial at 4~24 h.CONCLUSION:
ART can induce the marked sustained increase of[Ca2+]i and [Ca2+]i might play an important role in ART-induced apoptosis of human PC-3 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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