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Study on Self-Assembling Peptide In-Situ Gel as Potential Protein Carrier / 中国药房
China Pharmacy ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-531915
ABSTRACT

OBJECTIVE:

To investigate the feasibility of introducing self-assembling peptides as protein drug carrier.

METHODS:

By using RAD16-Ⅰ as a model of self-assembling peptides,lysozyme as the model of protein drug,the property of self-assembling peptide solution containing protein to form hydrogel in-situ were characterized by rheology,and the property of protein release in vitro from self-assembling peptide in-situ hydrogel was studied.

RESULTS:

The self-assembling peptide RAD16-Ⅰ can form hydrogel with certain mechanical intensity rapidly after its solution contained protein being mixed with PBS.Proteins can release easily from RAD16-Ⅰ hydrogel in a sustained-release manner to some extent.About 80% of proteins can be released from the hydrogel within 8 hours and the cumulative protein release from 1.5% hydrogel was less than 90%.The bio-activity of lysozyme released from RAD16-Ⅰ hydrogel was well preserved as 98% to 115%.

CONCLUSION:

Self-assembling peptide can be employed as potential in-situ hydrogel carrier for protein drugs.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article