Preparation and Release Rate in Vitro of Clomipramine Hydrochloride Sustained-release Tablets / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-532226
ABSTRACT
OBJECTIVE:
To prepare clomipramine hydrochloride sustained release tablet and study its in vitro release rate.METHODS:
Orthogonal experiment was carried out to optimize the formulation and the preparation was prepared taking by the formula dosage of HPMC,lactose and amylum pregelatinisatum as factors and the in vitro release rate as index.The in vitro drug release rate was investigated as well.RESULTS:
The optimal formulation was as follows HPMC 45 mg,lactose 35 mg,and amylum pregelatinisatum 40 mg.The preparation prepared in the optimal formulation had a sustained release of 24 h and the release behavior of the tablets followed the zero order equation.CONCLUSION:
The formula of the sustained release tablets is reasonable and which had satisfactory sustained release efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS