Determination of the Dissolution of Sitafloxacin Tablets / 中国药房

ABSTRACT

OBJECTIVE: To establish a method for the determination of the dissolution of sitafloxacin tablets.METHODS: The dissolution sitafloxacin tablets was determined by peddle method in accordance with Chinese Pharmacopeia(2005 edition) using 0.1 mol?L-1 HCl as the medium with the rotation speed set at 75 r?min-1.Sampling was carried at 30 min with its absorbability determined by UV spectrophotometry under a wavelength of 295 nm and its dissolution rate calculated.RESULTS: The linear range of sitafloxacin was 2～20 ?g?mL-1(r=0.999 6) with an average recovery rate of 99.95%(RSD=0.40%).The dissolution rates of 3 batches of samples were all above 90%.CONCLUSION: The method is simple,accurate with reliable results,and it is applicable for the determination the dissolution rate of sitafloxacin tablets.