Preparation Technology of Curcumine Solid Lipid Nanoparticles / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-532473
ABSTRACT
OBJECTIVE:
To prepare Curcumine solid lipid nanoparticles(Cur-SLN).METHODS:
Cur-SLN was prepared by emulsification evaporation-solidification at low temperature.The formulation of Cur-SLN was optimized by orthogonal experiment with the contents of curcumine,poloxamer 188,docosanoic acid glyceride lecithin used as factors and with entrapment efficiency as index;meanwhile,the appearance,particle size,surface potential,entrapment efficiency and the release profile of curcumine in vitro were studied.RESULTS:
The optimized preparation conditions were as followsthe contents of curcumine,poloxamer,docosanoic acid glyceride lecithin were 8 mg,320 mg,140 mg and 320 mg,respectively.The Cur-SLN assumed spherical shape with particle size at(134?5)nm,entrapment efficiency at(67.4?1.3)% and mean surface potential at(-23.5?1.5)mV.The release profile of curcumine in vitro fitted Higuchi equation.CONCLUSION:
It is feasible to prepare Cur-SLN by emulsion evaporation-solidification at low temperature,and the study results serve as experimental evidence for developing new curcumine injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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