Determination of Main Component in Ciprofloxacin Lactate Chitosan Nasal Drop by RP-HPLC / 中国药房
China Pharmacy
; (12)2005.
Article
in Zh
| WPRIM
| ID: wpr-532485
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To determine the content of ciprofloxacin in ciprofloxacin lactate chitosan nasal drops by RP-HPLC.METHODS: The sample was separated on XTerra RP18 chromatographic column with 0.05 moL?L-1 citric acid-acetonitrile(80∶20) as mobile phase at a flow rate of 0.8 mL?min-1.The detective wavelength was set at 277 nm;The sensitivity was 2.000 AUFS;The column temperature was maintained at 30 ℃ and the sample size was 10 ?L.RESULTS: The linear ranges of ciprofloxacin lactate was 10~200 ?g?mL-1(r=0.999 9) and its average recovery rate was 99.46%(RSD=1.13%).CONCLUSION: This method is rapid,accurate and suitable for the determination of the content of ciprofloxacin in ciprofloxacin lactate chitosan nasal drops.
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Index:
WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
2005
Type:
Article