Alteration of lymphocyte P-gp expression level and function in liver transplant recipient / 中国普通外科杂志

ABSTRACT

Objective To investigate the alteration of lymphocyte P-gp expression level and function in liver transplant recipient and its effect on immunosuppressive therapy.Methods Using flow cytometry,the level of lymphocyte P-gp and analyzed the P-gp function in 53 cases of liver transplant recipieints was observed.Results Among 53 cases,the preoperative mean level of lymphocyte P-gp was(10.34?4.0)%,P-gp level began to increase in the 1st month postoperatively(17.8?8.0)%,peaked in the 3rd month(27.5?13.3)%,and then was stable at this level thereafter.There were no significantly difference between different sex of age group.But the P-gp level in CD+4T cells was significantly higher than that in CD+8T cells and B cells,RH123test showed that high P-gp expression of lymphocyte enhanced its transport activity of medical agents,and decreased the intracellular accumulation of drug more significantly than that of low P-gp expression(P