Distribution of Paeonol in Plasma and Brain Tissue of Mice / 中国药房

ABSTRACT

OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice.METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC-MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated.RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows Ka(99.3 h-1 vs 18.22 h-1);t1/2?(0.04 h vs 0.05 h);t1/2?(3.95 h vs 71.23 h);t1/2ka(0.01 h vs 0.04 h);Cmax(4.57 ?g?mL-1 vs 0.51 ?g?g-1);AUC0→t∶2.32 ?g?mL-1?h,1.62 ?g?g-1?h.CONCLUSION: After intragastric administration,paeonol rapidly absorbed by mice and quickly eliminated from plasma,and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.