Therapeutical Effect of Zangfukang Suppository on Experimental Vaginitis in Rats / 中国药房

ABSTRACT

OBJECTIVE: To evaluate the therapeutic effect of Zangfukong suppository on the experimental vaginitis.METHODS:The experimental rats were equally assigned to 6 groups normal control group,model control group,gyno-daktarin(0.12 g?kg-1) group,three Zangfukang groups(0.33 g,0.17,and 0.08 crude drug? kg-1).Candida albicans solution was injected into the vigina of the estrous rats to establish colpomycosis model.The effect of Zangfukang suppository on the infection rate of candida albicans was observed.The bacterial vaginitis model was established by injecting the mixture bacteria of Neisseria gonorrhoeae,staphylococcus aureus and escherichia coli into the vagina of rats,and the effect of Zangfukang suppository on the gonococcal infection rate.RESULTS: After local application of Zangfukang suppository for 7 consecutive days for treatment of colpitis mycotica of rats,the infection rates of candida albicans were significantly lower in medium-dose and high-dose groups than in the model control group(P