Curative Efficacy of Telmisartan for Pulmonary Hypertension in Patients with COPD in Acute Exacerbation Stage / 中国药房

ABSTRACT

OBJECTIVE: To observe the clinical efficacy of telmisartan for patients with chronic obstructive pulmonary disease(COPD) in acute exacerbation stage(AECOPD).METHODS: 72 AECOPD cases with pulmonary hypertension(PAH) were divided into control group and treatment group.The control group received routine therapy alone,and the treatment group received Telmisartan additionally for 14 days in addition to the routine therapy.The major outcome measures including the pulmonary artery pressure and the changes of PAH on X ray in the two groups were observed before and after treatment.RESULTS: In the treatment group compared with before treatment within the same group or compared with the control group,oral telmisartan significantly down-regulated mPAP and the PAH parameters on X-ray including right descending pulmonary artery(RDPA),RDPA/ tracheal transverse diameter,convexity of pulmonary artery etc.CONCLUSION: Telmisartan has remarkable efficacy in decreasing pulmonary hypertension in patients with AECOPD.