Optimization on the Formulation Technology of Paeonol-?-cyclodextrin Inclusion Compound / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-532801
ABSTRACT
OBJECTIVE:
To optimize the formulation technology of paeonol-?-cyclodextrin inclusion compound.METHODS:
The formulation technology of paeonol-?-cyclodextrin inclusion compound was optimized by performing orthogonal experiment with the amount of ?-cyclodextrin,the solid-liquid ratio (ratio of ?-cyclodextrin to paeonol alcohol solution),the concentration of the envelop liquid (alcohol) as factors and the ultrasonic time was studied by single factor test and with the utilization ratio and entrapment efficiency of paeonol as indexes for evaluation. Meanwhile,a verification test was performed.RESULTS:
The optimal formulation technology was as follows the amount of ?-cyclodextrin was 8 g;the solid-liquid ratio was 1∶3;the concentration of the alcohol was 40% and the ultrasounding time was 40 min. The verification test revealed that the labeled contents were about 90% for all samples (4 batches).CONCLUSION:
The optimized formulation technology is simple and reasonable,and it is applicable for the preparation of paeonol-?-cyclodextrin inclusion compound.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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