Compatibility of Danshen Injections and Quinolones Injections / 中国药房

ABSTRACT

OBJECTIVE:To study the compatibility of Danshen Injections (in different dosage forms) and Quinolones Injections (in different varieties). METHODS:The contents of tanshinol sodium,protocatechualdehyde and tanshinone ⅡA in Danshen Injections as well as the contents of different Quinolones after mixing Danshen Injections (in different dosage forms) with Quinolones Injections (in different varieties) were determined by HPLC. The pH values of the mixtures were detected by acidometer and the properties of the mixtures were observed. RESULTS:After mixing of two,turbid reactions were noted in all the infusions of Quinolones; the contents of tanshinol sodium and protocatechualdehyde in the mixture were stable,whereas the content of tanshinone ⅡA decreased to almost 0; and the contents of Quinolones decreased slightly,and which were measured at about 90% of the labeled amount. The infusion reactions were independent of the pH value. CONCLUSION:Danshen Injection can't be mixed with Quinolones Injection in the same container; instead,they should be placed with suitable infusion separation and infused singly in different time period.