Determination of Main Component in Megestrol Acetate Tablets by RP-HPLC / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-532947
ABSTRACT
OBJECTIVE:
To establish the RP-HPLC method for the determination of main component in megestrol acetate tablets.METHODS:
RP-HPLC was carried out using a SinoChrom OPS-AP column with column temperature kept at room temperature.The detection wavelength was set at 288 nm.The mobile phase was composed of water-acetonitrile(20∶80,containing 2% triethylamine,pH 5.28)at a flow rate of 1.0 mL?min-1 with dixiben served as internal standard.The injection volume was 20 ?L.RESULTS:
The standard curve was linear over the range of 7~336 ?g?mL-1 for megestrol acetate(r=0.999 6)and its recovery rate was 99.95%(RSD=0.51%).CONCLUSION:
The method is simple,reproducible and accurate,and it is applicable for the determination of the megestrol acetate tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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