Determination of Plasma Ozagrel Concentration by RP-HPLC / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-533102
ABSTRACT
OBJECTIVE:
To determine the concentration of ozagrel in human plasma by RP-HPLC.METHODS:
The sample separation was performed on a SinoChrom OPS-AP column.The mobile phase consisted of 0.025 mol?L-1 potassium dihydrogen phosphate buffer solution-acetonitrile(85∶15) with a flow rate of 0.8 mL?min-1 and a detection wavelength of 274 nm.The internal standard was levodropropizine.RESULTS:
The linear range of ozagrel was 0.7~21.3 ?g?mL-1,(r=0.999 6).The extraction recovery of ozagrel was 83.78%~89.14% and the methodological recovery of it was 101.95%~106.68%.The intra-day RSD and inter-day RSD were 1.33%~3.27% and 2.72%~5.97%,respectively.CONCLUSION:
This method is simple,rapid,accurate and reproducible,and it is applicable for the pharmacokinetic study of ozagrel in human plasma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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