Effect of Combination of Propofol and Midazolam on Learning Memory of Mice / 中国药房

ABSTRACT

OBJECTIVE:To observe the effect of the combination of propofol and midazolam on learning memory of mice.METHODS:Fifty mice were divided into 5 groups(n=10)NS group(normal saline,subcutaneously),LM group(10% intralipid,peritoneal),MZ group(1 mg?kg-1 midazolam,subcutaneously),PP group(20 mg?kg-1 propofol,peritoneal) and MP group(combination of 0.5 mg?kg-1 midazolam and 10 mg?kg-1 propofol).Latency and error times in each group were observed by step-down test and step-through test so as to evaluate the effect of medicine on learning memory of mice.RESULTS:On the 1st and 2nd day after medication,significant differences were noted in error times and latency in MP group,PP group and MZ group,as compared with NS group and LM group(P0.05).Compared with MZ group,reduction of error times and prolongation of latency were noted in MP group and PP group on the 2nd day after medication(P0.05).CONCLUSION:Combination of propofol and midazolam(half dose) can result in hypofunction of learning memory of mice as well as they are used alone.Synergistic action is performed between propofol and midazolam.