Protective Effect of Meloxicam on Aluminum Overload-inducing Damage of Hippocampal Neuron in Rats / 中国药房

ABSTRACT

OBJECTIVE:To investigate the protective effect of meloxicam on aluminum overload-inducing damage of hippocampal neuron.METHODS:Primary hippocampal neuron attained from new born SD rats was cultured for 7 days.There were 5 groups e.g blank control group (200 ?mol?L-1 NaCl),aluminum model group (200 ?mol?L-1 AlCl3) and meloxicam low-dose (10-8 mol?L-1),medium-dose (10-7 mol?L-1) and high-dose (10-6 mol?L-1) groups.HE staining was used to observe the change of neuronal morphology.The optical densities of cells were measured.The activities of SOD,leakage of LDH and content of MDA were also detected.RESULTS:As compared with control group,the optical density of cells and activity of SOD were decreased and leakage of LDH and content of MDA were increased (P