Effects of Shenqi Bufei Decoction on Air Passage and Lung Function of COPD Model Rats with Lung-qi Deficiency / 中国药房

ABSTRACT

OBJECTIVE: To observe the effects of Shenqi bufei decoction on air passage and lung function of COPD model rats with lung-qi deficiency.METHODS: Quantitative stimulation with tobacco and SO2 and papain aerosol inhalation were used to establish model COPD rats with lung-qI deficiency.Sixty male rats were randomly divided into normal group (N),model group(M),low dose treatment group(LT),medium dose treatment group (MT),high dose treatment group (HT),and glucocorticoid treatment group (GCT).Pathomorphological change of lung tissue in rats was observed with light microscope.The thickness of airway wall and smooth muscle layer of the small airway and lung function were measured by means of semi-quantitative image analysis system with lung function detection and analysis system respectively.RESULTS: As compared to N group,in M group the thicknesses of the small airway wall and smooth muscle layer were significantly increased(P