Effect of Atorvastatin on Intima-media Thickness and Endothelial Function of Internal Carotid / 中国药房

ABSTRACT

OBJECTIVE:To probe into effect of atorvastatin on Intima-media thickness and endothelial function.METHODS:60 patients with mild and moderate angiostegnosis of internal carotid were randomized into control group (n=30,0.1 g aspirin enteric-coated tablet) and experiment group (n=30,0.1 g aspirin enteric-coated tablet and 20 mg atrovastatin).Intima-media thickness and endothelial function were compared in 3 and 6 months before vs.after treatment.RESULTS:As compared with before treatment,intima-media thickness and endothelial function in experiment group were improved significantly after treatment (P0.05).CONCLUSION:Atorvastatin shows good effect on,improvement of intima-media thickness endothelial function,stabilization of atheromatous plaque,delay and prevention of angiostegnosis.