Pharmacokinetics of Sinomenine Enteric Tablet in Beagle Dogs / 中国药房

ABSTRACT

OBJECTIVE:To study the pharmacokinetics of sinomenine enteric tablet in Beagle dogs. METHODS:A single oral 1d2o0se, o2f4 01,0 mangd? 4k8g0-1 msiinno imn epnliansem ean tsearmicp tlaeb(le2t wmaLs) gwiveerne tdoe t8e rBmeiangelde bdyo gHs.P TLhCe. Tcohnec epnhtarramtioacno okfi nseitnico mpeanrainmee taetr s0 ,w1er5e, c3a0lc,u6la0t,ed9 b0,y 3p97 pharmacokinetic program. RESULTS:The concentration-time curves of sinomenine fitted to one-compartment model in the (adn8odg7 s.6e. l2iTm?hien2 a8mt.i2oa6ni)n i nmp hiBnae;ramgAalUec oCdko0i～gnTse.t(ic 2p8a.4ra3m?e3te.4rs8 )w?erg?e masi n?fomlloLw-s1. CtOmaNxC(L6U9S.6I6O?N16S.i4n1o)memniinn;e eCnmtaexri(c 0ta.b1l3e?ts s0h.0o2w)ed? gra?pimd La-bs1o;rpt1t/i2oken