Effects of Ethanol Extract of Zingiber officinale against Myocardial Ischemia-reperfusion Injury in Rats / 中国药房

ABSTRACT

OBJECTIVE: To study the effects ethanol extract of Zingiber officinale against myocardial ischemia-reperfusion injury in rats. METHODS: 50 female SD rats were randomly divided into sham group, model group, ethanol extract of Z. officinale groups (low, medium, high-dose group). Acute regional myocardial ischemia-reperfusion injury model was induced with ligation of rat heart left anterior descending coronary artery for 30 min and 90 min of reperfusion. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) were measured while transmission electron microscopy (TEM) was applied to detect the changes in myocardial ultrastructure. RESULTS: As compared with sham group, the content of MDA in model group was significantly increased but the activity of SOD was decreased (P