Analysis 1 Case of Literature on Grand Mal Epilepsy Induced by Levocarnitine and Literatures Analysis / 中国药房

ABSTRACT

OBJECTIVE: To analyze the literatures on grand mal epilepsy caused by levocarnitine,explore the causes of seizures, the clinical features and treatment measures in order to provide guidance for rational use of drug. METHODS: Included studies retrieved from CNKI and VIP in china journal of medicine from 1999～2009.Based on a grand mal epilepsy case caused by levocarnitine for Injection in our hospital, cases of grand mal epilepsy caused by levocarnitine reported in literatures were analyzed comprehensively. RESULTS: The clinical information of grand mal epilepsy cases reported in our hospital and literatures were analyzed as well as past medical history, usage and dosage, onset time, treatment method and efficacy. All patients were in the process of irrigation of Levocarnitine showed the typical clinical manifestations of grand mal epilepsy, after active treatment were both mitigation. CONCLUSION: The adverse reaction that grand mal epilepsy is caused by levocarnitine is rare,and pathogenesis is not clear but clinicians should pay attention to it.