Determination of the Main Component of Captopril Tablets by Derivative Spectrophotometry / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-533804
ABSTRACT
OBJECTIVE:
To establish derivative spectrophotometry for the determination of the main component of Captopril tablets.METHODS:
Under the alkaline condition of sodium hydroxide,2,4-dinitrofluorobenzene was used as derivatization reagent to react with captopril at 40 ℃ in the water bath.Then UV spectrophotometry was adopted to detect the content of captopril with detection wavelength set at 342 nm.RESULTS:
The linear range of captopril was 1.0~14.0 ?g?mL-1(r=0.999 9) with an average recovery of 99.61%(RSD=1.27%,n=9).The RSD of intra-day and inter-day both were less than 2%.CONCLUSION:
This method is stable,reliable,rapid and simple for the determination of the main components of Captopril tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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