Determination of Residual Organic Solvents in Letrozole by Headspace Capillary Gas Chromatography / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-533942
ABSTRACT
OBJECTIVE:
To establish headspace capillary gas chromatography for the content determination of residual solvents in letrozole, such as chloroform, ethanol, acetone, ethyl acetate, DMF and isopropanol.METHODS:
Dissolved in dimethyl sulfoxide, chloroform, ethanol, acetone, ethyl acetate, DMF and isopropanol in letrozole were determined by headspace gas chromatography with HP-5 capillary gas chromatography. ECD was applied for chloroform, while FID was applied for the other residual solvents.RESULTS:
The liner ranges of chloroform, ethanol, acetone, ethyl acetate, DMF and isopropanol were 1.028~10.28 mg?L-1(r=0.999 9), 94.68~946.8 mg?L-1 (r=0.999 7), 94.64~946.4 mg?L-1(r=0.999 7), 110.64~1 106.4 mg?L-1(r=0.999 7), 15.12~151.2 mg?L-1(r=0.999 6), 116.48~1 164.8 mg?L-1(r=0.999 5), respectively. The average recoveries of the residual organic solvents ranged from 97% to 102%. The detection limits were 20~90 ?g?L-1. The residual levels of the six organic solvents in three batches of samples were all up to the standard stipulated in Chinese Pharmacopeia.CONCLUSIONS:
The method is simple, sensitive, accurate and reliable for the content determination of residual organic solvents in letrozole.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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