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Determination of Peroxide Value in Hydroxycamptothecin Freeze-dried Liposome / 中国药房
China Pharmacy ; (12)2005.
Article in Chinese | WPRIM | ID: wpr-533944
ABSTRACT

OBJECTIVE:

To establish a method for the determination of the peroxide value of hydroxycamptothecin freeze-dried liposome.

METHODS:

Colorimetric method with ferric thiocyanate and UV spectrophotometry were adopted for the content determination of peroxide value at detection wavelength of 500 nm.

RESULTS:

The linear range of iron was 0.2~4 ?g?mL-1 (r=0.999 0) with an average recovery of 99.2% (RSD=1.2%, n=9). The peroxide value of 3 batches of hydroxycamptothecin freeze-dried liposome was 0.48,0.45,0.43 mmol?kg-1.

CONCLUSION:

The method is sensitive and precise for the determination of the peroxide value of liposome.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article