Determination of adventitous agent in monkeys and monkey kidney cells culture using for OPV production in 2006
Journal of Preventive Medicine
;
: 5-9, 2007.
Article
in Vietnamese
| WPRIM
| ID: wpr-534
ABSTRACT
Background:
In 2006, Center for research and production of vaccines and biologicals \ufffd?Ha Noi produced 10 million doses of poliomyelitis vaccine met quality standard which given by World Health Organization (WHO). The monkeys for vaccine production were selected and monkey kidney cells were tested arcording to the WHO requirements (the strong moykeys with no adventitous agents).Objectives:
To assess the rates of mokeys (at the Reu island in Quang Ninh province) with no adventitous agent infection and the cells using to produce type 1 poliomyelitis vaccine in 2006. Subjects andmethod:
The study was performed by using microneutralization technique on 39 Macaca mulatta mokeys with weights were 1.5 to 2.5 kg.Results:
11 out of 39 monkeys (28,21%) are negative to SIV, SV40, poliomyelitis viruses, foamy virus as well as tuberculin test. 100% lots of primary monkey kidney cells culture produced in 2006 are free from adventitous agents arcording to the WHO requirements.Conclusion:
Center for research and production of vaccines and biologicals - Ha Noi implemented strictly under the WHO guidelines on selection of monkeys and monkey kidney cells for OPV production from Sabin strains.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Poliovirus Vaccine, Inactivated
/
Haplorhini
/
Macaca mulatta
Language:
Vietnamese
Journal:
Journal of Preventive Medicine
Year:
2007
Type:
Article
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