A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in Child / 대한피부과학회지
Korean Journal of Dermatology
;
: 970-974, 2013.
Article
in Korean
| WPRIM
| ID: wpr-53409
ABSTRACT
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematopoietic malignancy which is derived from the precursors of plasmacytoid dendritic cells and is more infrequent in children than in adults. Formerly known as blastic NK-cell lymphoma or CD4+/CD56+ hematodermic neoplasm, the BPDCN is reclassified into the group of acute myeloid leukemia and related neoplasm by WHO in 2008. An 8-year old girl is being presented with bruise-like subcutaneous nodules with purpura on her right cheek from the performed biopsy. Histological examinations show sheet-like dense infiltrations of medium-sized lymphoid cells with irregular nuclei in the entire dermis. Immunohistochemical stainings of tumor cells were positive for CD4, CD56, LCA, TCL-1, TdT and focal positive for CD3, CD7, CD45RO and negative for CD20, CD30, CD34, EBV. The PET-CT scans indicate hot uptakes in the bone marrows which are suggestive of malignant infiltrations, and bone marrow biopsy findings are consistent with BPDCN of leukemic transformations. We present a rare case of BPDCN which affects the pediatric patient.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Purpura
/
Biopsy
/
Bone Marrow
/
Dendritic Cells
/
Lymphocytes
/
Leukemia, Myeloid, Acute
/
Cheek
/
Herpesvirus 4, Human
/
Hematologic Neoplasms
/
Dermis
Limits:
Adult
/
Child
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2013
Type:
Article
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