Effect of Reteplase Combined with Low-molecular Heparin Sodium in the Treatment of Early Acute Cerebral Infarction / 中国药房

ABSTRACT

OBJECTIVE:To observe efficacy and safety of reteplase combined with low-molecular heparin sodium intravenous thrombolysis in the treatment of early cerebral infarction.METHODS:102 cases of early acute cerebral infarction from Jan.2007 to Aug.2009 were received intravenous thrombolytic therapy.52 cases were treated with reteplase combined with low-molecular heparin sodium as observation group and 50 cases were treated with reteplase as control group.The neurological deficit scores(NIHSS) values at 1,7 and 14 d before and after treatment were compared between 2 groups.The complication of 2 groups were evaluated after treatment.RESULTS:The NIHSS score in observation group were decreased significantly as compared with control group,there were significant difference(P0.05).CONCLUSION:Intravenous administration of 10 MU reteplase combined with 5 000 U?12 h-1 low-molecular heparin sodium is superior to reteplase alone in the treatment of acute cerebral infarction.Reteplase combined with low-molecular heparin sodium does not increase the risk of bleeding in key site of patients(including the elderly).