Genetic Polymorphisms of CYP3A4 in Epilepsy Patients Treated with Carbamazepine / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-534236
ABSTRACT
OBJECTIVE:
To investigate the genetic polymorphisms of cytochrome P4503A4(CYP3A4) in epilepsy patients treated with carbamazepine,and to provide reference for individual drug regimen.METHOD:
Blood samples were collected from epilepsy patients treated with carbamazepines.Mutations in CYP3A4 gene were detected by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).RESULTS:
After screening the 141 subjects,the individual mutation rates of the allele CYP3A4*4 and CYP3A4*6 were 0.71%.No allele CYP3A4*5 was found in 141 subjects.CONCLUSION:
CYP3A4 genetic polymorphisms may change the activity of CYP3A4 gene.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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