Preparation of Osthole Microemulsion and Its Transdermal Absorption / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-534362
ABSTRACT
OBJECTIVE:
To prepare osthole microemulsion and investigate its in vitro transdermal absorption ability.METHODS:
The blank microemulsion formula was optimized based on the solubility of osthole in different oil phase,emulsifier,co-emulsifier and pseudo-tertiary phase diagrams.The viscosity,conductance and particle size of osthole microemulsion were investigated.The permeation rate of osthole was determined using drug diffusion apparatus.RESULTS:
The viscosity,conductance and mean particle size of osthole microemulsion were 8.07 mpa?s,123 ?S?cm-1,58.0 nm,respectively.The steady permeation rate of osthole microemulsions reached(33.042?3.1)?g?cm-2?h-1(r=0.995 0)and it was 25.5 times over that of saturated osthole solution.CONCLUSION:
The result indicates osthole microemulsion with high permeation rate may be used as new osthole preparation with transdermal delivery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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