Study on Fragmentation Pathways of Amoxicillin by Electrospray Ionization Multi-stage Tandem Mass Spectrometry / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-534415
ABSTRACT
OBJECTIVE:
To investigate fragmentation pathways of amoxicillin using electrospray ionization multi-stage tandem mass spectrometry,and to provide reference for quality and quantity analysis of amoxicillin.METHODS:
Amoxicillin was further purified by high performance liquid chromatography,and the fragmentation mechanisms were investigated by electrospray ionization multi-stage tandem mass spectrometer.RESULTS:
The ?-lactam ring of amoxicillin has three different opening modes;2 kinds of different m/z114 ion fragments are obtained by two different fragmentation pathways;m/z349 ion fragments can be a characteristic fragment of amoxicillin for quality and quantity analysis of amoxicillin.CONCLUSION:
The method is sensitive and accurate for further study of transformation and metabolism of amoxicillin and its quality and quantity analysis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
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