Determination of the Dissolution of Eslicarbazepine Acetate Tablets / 中国药房

ABSTRACT

OBJECTIVE: To establish the method for the dissolution determination of Eslicarbazepine acetate tablets.METHODS: Samples were collected at 30 min with phosphate buffer solution(pH=4.5) as solvent and rotation speed of 50 r?min-1 according to second dissolution determination method(slurry method) stated in Chinese Pharmacopeia(2010 edition).The absorbance of 3 batches of samples was determined by UV spectrophotometry at detection wavelength of 288 nm.RESULTS: The method showed a good linear relationship in the range of 5～30 ?g?mL-1(r=0.999 8) with an average recovery of 99.74%(RSD=0.47%).The dissolutions of 3 batches of samples were 82.06%,82.72% and 82.64%,respectively.CONCLUSIONS: Established method is simple and reliable for the dissolution determination of Eslicarbazepine acetate tablets.