Your browser doesn't support javascript.
loading
Literature Analysis of 45 ADR Cases Induced by Lefunomide / 中国药房
China Pharmacy ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-534524
ABSTRACT

OBJECTIVE:

To investigate the characteristics and regularity of ADR cases caused by leflunomide, and to provide reference for rational use of it.

METHODS:

Literatures about leflunomide-inducing ADR were retrieved from CNKI between 1994 and Apr. 2010. Those literatures were statistically analyzed in respect of patient’s age and gender, route of administration, dosage of drugs, onset time of ADR, organs and systems involved in ADR and its clinical manifestations, treatment and outcomes, etc.

RESULTS:

37 pieces of literatures were obtained with standard cases of 45. The incidence of ADR cases in female(75.56%) was higher than in males (24.44%). 28 ADR cases were in 50~60 group. 39 patients were treated with leflunomide 10~30 mg once a day. After treatment, the most common gastrointestinal adverse events occurred in 1~15 d. Leflunomide-inducing ADR was digestive system reaction (75.56%) the most. Patients who took medicine less than 10 days with mild ADR need not to stop taking medicine when clinical symptoms reduced or disappeared after symptomatic treatment. Patients who took medicine more than 10 days with severe ADR need to stop taking medicine and receive symptomatic treatment.

CONCLUSION:

Clinical physicians should pay attention to rational use of leflunomide and ADR during treatment course to reduce the harm due to adverse events.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article