Circulating Immune Complexes in Patients with Gastric Cancer / 中国免疫学杂志

ABSTRACT

186 serum samples from 81 patients with gastric cancer were determined for circulatingimmune complexe (CIC) by using the polyethylene glycol turbidity assay. Compared with 105healthy blood donors, the mean value of CIC were significantly increased in pretreatment pati-ents (47.46?24.52vs.27.67?12.09), and the corresponding figures for stage Ⅰ+Ⅱ, Ⅲ and stage Ⅳpatients were 38.60?14.24, 42.04?13. 18 and 54.31?29. 15 respectively. The incidence of positivityof CIC in pretreatment patients was 32.1%. The mean value of CIC is significantlyhigher in patients whose disease could not be treated with radical surgery than in patientswhose disease could.CIC levels increased significantly during 11～45 days after radical operation.CIC levels were positive correlated with levels of serum IgA, IgM, C_3, and negative corre-lated with the rate of lymphocyte transformation. The patients found positive for ANA hadhigher incidence of positivity of CIC than those found negative for ANA.The clinical signifi-cance of CIC in patients with gastric cancer was also discussed.