Studies of the augmenting effect of selenium (Se) on ceil-mediated immunity—The effect of Se on T cell function in mice / 中国免疫学杂志

ABSTRACT

In this paper,the in vitro and in vivo effect of Se on T cell function was presented. Mouse spleen lymphocytes cultured in the presence of sodium selenite(30～1,000ng/ml)showed increased proliferation in response to Concanavalin A,but sodium selenite itself was not mitogenic.When sodium selenite was added into one-way mixed lymphocyte culture (MLC),not only was the proliferation of the responder cells increased,the induction of cytotoxic T lymphocytes(CTL)was also enhanced.In mice given Se(2-4ppm)in drink- ing water,the activity of MLC-induced CTL was higher than in untreatedcontrols.The augmented cytotoxic activity of CTL was alloantigenspecific.