CLINICAL SIGNIFICANCE OF GLUCOSE INSULIN RELEASE TEST AND SOME INSULIN ANTAGONISTIC HORMONES DETERMINATION IN NORMAL PREGNANT WOMEN / 中华内分泌代谢杂志

ABSTRACT

Glucose insulin release test together with IGI (insulin genetic index) and determinations of some insulin-antagonistic hormones such as hGH (HPL), TT3, TT4, 135I-T3 MAA absorbing ratio were carried out in 90 normal pregnant women. The results indicated that (1) the fasting plasma glucose level was lower as compared with that of the non-pregnant control group, especially during the second trimester; (2) subclinical hypoglycaemia appeared in about 18% of the pregnant women during the first and second trimesters;(3) some insulin-antagonistic hormones, especially HPL (human placental lactogen), which was crossreactive to hGH, augmented load of pancreatic islet; (4) augmentation of load of pancreatic islet might be demonstrated by fasting hyperinsulinemia, elevation of postprandial plasma glucose level especially during the third trimester and increased IGI response during the second trimester-after glucose intake, It was suggested that pregnancy might lead to diabetic susceptibility, and that an over-weight or pregnant woman suspected of diabetes mellitus should be moni-tored carefully with OGTT during gestation.