L P immunocytoma:Cytological double-labelled immunofluorescence study for one case / 中国免疫学杂志

ABSTRACT

One case of LP immunocytoma was studied by double-labelled immunofiuorescentstaining method using different immuno-fluorescent antibodies against Ig heavy andlight chain for patient's peripheral blood lyphoid cells.It was found that the malignentcells composed of lymphocyte,plasmacytoid lymphocytes and lymphoblasts were shownto have M components of Kappa(K),lambda(?)IgG and ? in the same single cell on cellsurface and in the cytoplasma.Besides intracellular inclusion globules stained by rodamine labelled anti-X antibody and IF stained nucleoli were also revealed in same mali-gnent lymphoid cells.The authors emphasized that different heavy and light chaintypes of M proteins could be produced from monoclonal tumor cells.