FASTING PLASMA GLUCAGON LEVEL AND GLUCAGON RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA IN NORMALS AND NIDDM PATIENTS / 中华内分泌代谢杂志

ABSTRACT

Pancreatic A cell function was studied in 119 cases of NIDDM with 37 normal subjects as controls. In NIDDM group, fasting plasma glucagon leveh averaged 192.9 ? 129.6 pg /ml, whereas in normals being 132.8?65.0 pg / ml. Plasma glucagon levels were markedly elevated in patients with NIDDM irrespective of insulin administration, suggesting decreased pancreatic A cell sensitivity to glucose.In 7 male normal subjects, following intravenous injection of insulin (0.1 U / kg) an average increment of 114 pg / ml of plasma glucagon level with a peak at 30-60 min was noted. In 3 of 6 male diabetic subjects a paradoxical reduced plasma glucagon response to insulin-induced hypoglycemia was demonstrated, suggesting primary abnormality of pancreatic A cell function in NIDDM patients, with a possible defect in glucose counter-regulation.