pRELIMINARY STUDY OF T-CELL SUBSETS AND THEIR SERUM FACTOR IN CHRONIC HEPATITIS B / 中国免疫学杂志

ABSTRACT

42 patients with chronic hepatitis B virus(HBV)infection were studiedby enumeration of T-cell subsets in peripheral blood with SACI-Ig rosetteforming technique.Among which,10 patients with reduction of OKT_4/OKT_8 ratio were evaluated by assay the effect of their sera on T-cell su-bsets. OKT_4/OKT_8 atwas significantly lower in patients with HBeAg(+),serum HBV-DNA(+and HBcAg(+)of liver tissue than in normal con-trast.OKT_4/OKT_8 ratio of patients with chronic active hepatitis(CaH) was similar to that of pants with chronic persistant hepatitis(CPH).Itseoisprpoad fhat there isa relationship in OKT_4/OKT_8 ratio and HBV rep-lication. when lymphocytes from a normal individual were incubated with seraof 10 patients with reduction of OKT_4/OKT_8 ratio for 24-48 hours,OKT~+_8cell proportion was significantly increased.As lymphocytes from the samenormal individual were proportion incubated witn sera of 10 helthy donorsfor 24-48 hours,OKT~+_8 cell proportion was only moderately increased.It issuggested that there is a factor in sera of patients with chronic hepatitisB,which probably makes OKT~+_4 cell bear both OKT~+_4 and OKT_8~+antigenicmarkers.