THE NEGATIVE FEEDBACK REGULATION OF PITUITARY N-POMC SECRETION BY GLUCO CORTICOIDS WAS BLUNTED IN CUSHING'S DISEASE / 中华内分泌代谢杂志

ABSTRACT

The effect of hydrocortisone (135 nag i.v. as a bolus) on the levels of serum N-POMC was studied in the patients with Cushing's disease [including three groups untreated (CD, n=8), post-adrenolectomy without Nelson's syndrome (CDA, n=5), and Nelson's syndrome (NS, n=4)]; Addison's disease (AD, n = 13) and congenital adrenal hyperplasia (CAH, n=4). The results showed that the levels of serum N-POMC were decreased after the administration of hydrocortisone in all three groups of Cushing's disease, however the suppression rate of N-POMC was much lower in these groups than that in AD and CAH (P